Neuropeptide Y
Neuropeptide Y (NPY)
One of the most abundant neuropeptides in the brain. Regulates appetite, stress responses, anxiety, and cardiovascular function. Has complex effects depending on receptor subtype.
Mechanism of Action
NPY binds to Y1-Y5 receptors with different effects: Y1/Y5 stimulate appetite, Y2 inhibits neurotransmitter release, Y1 has anxiolytic effects. It modulates the HPA axis and has vasoconstrictive properties.
Health Claims & Evidence
Reduces anxiety and stress responses
Regulates appetite and energy balance
Cardiovascular regulation
Short-Term Effects
Appetite stimulation, potential anxiolytic effects.
Long-Term Effects
Research use primarily.
Side Effects
Appetite stimulation, potential cardiovascular effects.
Contraindications
Complex pharmacology. Not recommended for self-administration.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Neuropeptide Y and stress resilience
Heilig et al. · Neuropeptides · 2004
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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