Intermedin
Intermedin (IMD / Adrenomedullin 2)
A member of the calcitonin/CGRP peptide family with potent vasodilatory, cardioprotective, and anti-inflammatory properties.
Mechanism of Action
Intermedin binds to CLR/RAMP1, RAMP2, and RAMP3 receptors, activating cAMP pathways that produce vasodilation, reduce inflammation, and protect against ischemic injury.
Health Claims & Evidence
Potent vasodilation and blood pressure reduction
Cardioprotective effects
Anti-inflammatory effects
Short-Term Effects
Vasodilation, anti-inflammatory effects.
Long-Term Effects
Research use primarily.
Side Effects
Limited human data. Potential hypotension.
Contraindications
Limited human safety data.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Intermedin and cardiovascular regulation
Roh et al. · Journal of Biological Chemistry · 2004
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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