SS-31
Elamipretide (SS-31, MTP-131)
A mitochondria-targeted peptide that concentrates in the inner mitochondrial membrane. Protects mitochondrial function, reduces oxidative stress, and has shown remarkable results in heart failure trials.
Mechanism of Action
SS-31 selectively concentrates in the inner mitochondrial membrane where it interacts with cardiolipin, stabilizing cristae structure and electron transport chain function. It reduces mitochondrial ROS production and improves ATP synthesis efficiency.
Health Claims & Evidence
Improves mitochondrial function and energy production
Cardioprotective in heart failure
Reduces oxidative stress and aging markers
Improves exercise capacity
Short-Term Effects
Improved energy levels, reduced fatigue, enhanced exercise tolerance.
Long-Term Effects
Potential for sustained mitochondrial health improvements and anti-aging benefits.
Side Effects
Generally well-tolerated in trials. Mild injection site reactions.
Contraindications
Limited long-term human safety data. Use with medical supervision.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
SS-31 and mitochondrial protection in heart failure
Daubert et al. · JACC: Basic to Translational Science · 2017
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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