KGF
Keratinocyte Growth Factor (FGF-7)
A growth factor that specifically stimulates keratinocyte proliferation. FDA-approved (Kepivance) for oral mucositis in cancer patients.
Mechanism of Action
KGF binds to FGFR2b receptors on keratinocytes, stimulating proliferation, migration, and differentiation. It promotes epithelial repair in skin and mucous membranes.
Health Claims & Evidence
Promotes keratinocyte proliferation and wound healing
Reduces oral mucositis in cancer treatment
Supports hair follicle growth
Short-Term Effects
Accelerated epithelial healing, reduced mucositis.
Long-Term Effects
Clinical use only.
Side Effects
Skin rash, edema, mouth/tongue thickening.
Contraindications
Avoid with non-hematologic malignancies (potential tumor promotion).
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
KGF and oral mucositis prevention
Spielberger et al. · New England Journal of Medicine · 2004
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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