Resistin
Resistin (RETN)
An adipokine associated with insulin resistance and inflammation. Elevated in obesity and metabolic syndrome. Resistin antagonism is a potential therapeutic target.
Mechanism of Action
Resistin binds to TLR4 and CAP1 receptors, activating NF-kB pathways that promote insulin resistance and inflammation. It reduces insulin receptor signaling in liver and muscle.
Health Claims & Evidence
Biomarker for insulin resistance and metabolic syndrome
Pro-inflammatory effects
Resistin antagonism may improve insulin sensitivity
Short-Term Effects
Insulin resistance, inflammation.
Long-Term Effects
Research use primarily.
Side Effects
Insulin resistance, inflammation.
Contraindications
Not for self-administration.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Resistin and insulin resistance
Steppan et al. · Nature · 2001
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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