Apelin
Apelin (APLN)
An endogenous ligand for the APJ receptor with cardioprotective, vasodilatory, and metabolic effects. Apelin levels decline with age and heart failure.
Mechanism of Action
Apelin binds to APJ receptors on cardiomyocytes and vascular smooth muscle, producing positive inotropy, vasodilation, and anti-fibrotic effects. It also improves insulin sensitivity and has anti-aging properties.
Health Claims & Evidence
Cardioprotective and positive inotropic effects
Vasodilatory and blood pressure reduction
Improves insulin sensitivity
Short-Term Effects
Improved cardiac function, vasodilation.
Long-Term Effects
Theoretical cardioprotective and metabolic benefits.
Side Effects
Limited human data. Potential hypotension.
Contraindications
Limited human safety data.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Apelin and cardiovascular function
Tatemoto et al. · Biochemical and Biophysical Research Communications · 1998
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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