Livagen
Livagen (Lys-Glu-Asp-Pro)
A tetrapeptide bioregulator derived from liver tissue that activates chromatin and restores gene expression in aging cells. Used in longevity protocols targeting liver health, immune function, and epigenetic rejuvenation.
Mechanism of Action
Livagen acts as a chromatin activator, directly interacting with histone proteins to restore gene expression patterns silenced with age (epigenetic aging). It activates genes responsible for DNA repair, antioxidant defense, and immune regulation in hepatic and immune cells. In the liver it stimulates hepatocyte regeneration, reduces fibrotic changes, and normalizes detoxification enzyme activity. It also enhances NK cell and macrophage function, improving immune surveillance. Its chromatin-activating mechanism is distinct from other peptide bioregulators and makes it particularly relevant to epigenetic anti-aging strategies.
Health Claims & Evidence
Activates chromatin and restores gene expression in aging cells
Hepatoprotective — supports liver regeneration and detoxification
Restores innate immune function via NK cell and macrophage activation
Extends lifespan in animal models
Reduces oxidative stress and lipid peroxidation in hepatic tissue
Epigenetic rejuvenation — reverses age-related methylation patterns
Short-Term Effects
Improved energy, enhanced sense of well-being, potential improvement in liver enzyme markers.
Long-Term Effects
Epigenetic rejuvenation of aging cells, sustained liver health, improved immune surveillance, potential lifespan extension with repeated annual courses.
Side Effects
No significant adverse effects reported in available research. Well-tolerated in animal and limited human studies.
Contraindications
Limited human safety data. Caution in active hepatic disease until more clinical data is available. Avoid concurrent use with hepatotoxic agents.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Peptide regulation of chromatin in aging cells
Khavinson VKh, Vanyushin BF · Bulletin of Experimental Biology and Medicine · 2005
Hepatoprotective effects of liver-derived peptide bioregulators
Morozov VG, Khavinson VKh · Gerontology · 2001
Short peptides as epigenetic regulators of gene expression in aging
Khavinson VKh et al. · Frontiers in Genetics · 2013
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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