Galanin
Galanin (GAL)
A neuropeptide with widespread distribution in the nervous system. Modulates pain, memory, mood, appetite, and autonomic function.
Mechanism of Action
Galanin binds to GalR1, GalR2, and GalR3 receptors with different effects. GalR1 activation inhibits neuronal activity (analgesic, anxiolytic). GalR2 activation promotes neurogenesis. It modulates acetylcholine, norepinephrine, and serotonin systems.
Health Claims & Evidence
Modulates pain and produces analgesia
Promotes neurogenesis via GalR2
Modulates mood and anxiety
Short-Term Effects
Pain modulation, potential anxiolytic effects.
Long-Term Effects
Research use primarily.
Side Effects
Limited data for exogenous administration.
Contraindications
Research use only.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Galanin and neuropeptide pharmacology
Hokfelt et al. · Trends in Neurosciences · 1998
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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