Epithalon
Epithalamin / Epitalon (Ala-Glu-Asp-Gly)
A tetrapeptide derived from the pineal gland. One of the most studied longevity peptides, known for its ability to activate telomerase and extend telomere length.
Mechanism of Action
Epithalon activates telomerase enzyme, which elongates telomeres — the protective caps on chromosomes that shorten with age. It also regulates melatonin production via the pineal gland, normalizes circadian rhythms, and exhibits antioxidant and anti-tumor properties.
Health Claims & Evidence
Activates telomerase and extends telomere length
Extends lifespan in animal models
Normalizes melatonin and circadian rhythm
Antioxidant and anti-tumor effects
Short-Term Effects
Improved sleep quality, enhanced sense of well-being, mild antioxidant effects.
Long-Term Effects
Potential telomere preservation, improved immune function, and anti-aging effects with repeated cycles.
Side Effects
Extremely well-tolerated in studies. No significant adverse effects reported in decades of Russian research.
Contraindications
Limited data in pregnancy. Use with caution in individuals with autoimmune conditions.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells
Khavinson et al. · Bulletin of Experimental Biology and Medicine · 2003
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
Related Peptides
Explore the research further
Our AI Research Advisor can help you explore the evidence on Epithalon and related peptides, and prepare an educational research summary.
Explore Research