Bradykinin
Bradykinin (BK)
A vasoactive peptide that causes vasodilation, increases vascular permeability, and mediates pain and inflammation. Important in cardiovascular regulation and inflammatory responses.
Mechanism of Action
Bradykinin binds to B1 and B2 receptors. B2 receptor activation produces vasodilation (via NO and prostacyclin), pain sensitization, and increased vascular permeability. B1 receptors are upregulated during inflammation.
Health Claims & Evidence
Vasodilation and blood pressure reduction
Cardioprotective effects
Mediates pain and inflammation
Short-Term Effects
Rapid vasodilation, pain sensitization.
Long-Term Effects
Research use primarily.
Side Effects
Hypotension, pain, cough (when elevated by ACE inhibitors).
Contraindications
Not for self-administration.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Bradykinin and cardiovascular regulation
Bhoola et al. · Pharmacological Reviews · 1992
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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