CGRP
Calcitonin Gene-Related Peptide (CGRP)
A neuropeptide involved in pain transmission, vasodilation, and migraine pathophysiology. Anti-CGRP antibodies are FDA-approved for migraine prevention.
Mechanism of Action
CGRP binds to CLR/RAMP1 receptors, producing potent vasodilation and modulating pain transmission. It is released from trigeminal nerve endings during migraine attacks.
Health Claims & Evidence
Key mediator of migraine pathophysiology
Potent vasodilation
Modulates pain transmission
Short-Term Effects
Vasodilation (CGRP itself). Migraine prevention (anti-CGRP antibodies).
Long-Term Effects
Sustained migraine prevention with anti-CGRP antibodies.
Side Effects
Constipation (anti-CGRP antibodies), injection site reactions.
Contraindications
Use with caution in cardiovascular disease (CGRP has vasodilatory role).
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
CGRP and migraine pathophysiology
Edvinsson et al. · Nature Reviews Neurology · 2018
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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