Prokineticin-2
Prokineticin-2 (PROK2)
A neuropeptide that regulates circadian rhythms, pain sensitivity, and angiogenesis. Mutations in PROK2 or its receptor cause Kallmann syndrome.
Mechanism of Action
Prokineticin-2 binds to PROKR1 and PROKR2 receptors, regulating circadian clock output in the suprachiasmatic nucleus, modulating pain sensitivity, and promoting angiogenesis.
Health Claims & Evidence
Regulates circadian rhythms and sleep
Modulates pain sensitivity
Promotes angiogenesis
Short-Term Effects
Circadian rhythm modulation, pain sensitivity changes.
Long-Term Effects
Research use primarily.
Side Effects
Limited human data.
Contraindications
Limited human safety data.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Prokineticin-2 and circadian rhythms
Cheng et al. · Nature · 2002
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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