P21
P21 CNTF-Derived Peptide
A small peptide derived from ciliary neurotrophic factor (CNTF) that promotes neurogenesis, increases BDNF levels, and enhances cognitive function without activating the full CNTF receptor complex.
Mechanism of Action
P21 binds to the CNTFRα receptor component and activates downstream STAT3 and MAPK/ERK signaling without engaging gp130 or LIFRβ, avoiding the inflammatory side effects of full CNTF. This selective activation promotes hippocampal neurogenesis, increases BDNF expression, and enhances synaptic plasticity.
Health Claims & Evidence
Promotes hippocampal neurogenesis
Increases BDNF expression in the brain
Enhances spatial memory and learning
Short-Term Effects
Possible acute cognitive enhancement based on animal data.
Long-Term Effects
Animal data suggests sustained neurogenesis and cognitive improvement with continued use.
Side Effects
Unknown in humans. No significant adverse effects in animal studies.
Contraindications
Insufficient human data. Not for clinical use.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
P21, a CNTF-derived peptide, increases neurogenesis
Bhatt et al. · Neuropsychopharmacology · 2013
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
Related Peptides
Explore the research further
Our AI Research Advisor can help you explore the evidence on P21 and related peptides, and prepare an educational research summary.
Explore Research