Motilin
Motilin
A GI hormone that stimulates gastric and intestinal motility. Motilin receptor agonists (like erythromycin) are used for gastroparesis.
Mechanism of Action
Motilin binds to motilin receptors on GI smooth muscle and enteric neurons, stimulating the migrating motor complex (MMC) and gastric emptying.
Health Claims & Evidence
Stimulates GI motility and gastric emptying
Potential treatment for gastroparesis
Regulates the migrating motor complex
Short-Term Effects
Increased GI motility, accelerated gastric emptying.
Long-Term Effects
Research use primarily.
Side Effects
Abdominal cramping, diarrhea.
Contraindications
GI obstruction.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Motilin and GI motility
Brown et al. · Gastroenterology · 1971
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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