Neuropeptide AF
Neuropeptide AF (NPAF)
A neuropeptide that modulates opioid analgesia and pain processing. Has anti-opioid properties and modulates pain at the spinal level.
Mechanism of Action
NPAF binds to NPFF receptors (NPFFR1/2), modulating opioid receptor signaling and pain transmission. It has anti-opioid effects, reducing morphine analgesia and tolerance.
Health Claims & Evidence
Modulates opioid analgesia
Reduces opioid tolerance
Modulates pain at spinal level
Short-Term Effects
Opioid modulation, pain sensitivity changes.
Long-Term Effects
Research use primarily.
Side Effects
Limited human data.
Contraindications
Research use only.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Neuropeptide AF and opioid modulation
Roumy et al. · Neuroscience · 2003
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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