Pancreastatin
Pancreastatin (Chromogranin A Fragment)
A chromogranin A-derived peptide that inhibits insulin secretion and modulates glucose metabolism. Elevated in metabolic syndrome and type 2 diabetes.
Mechanism of Action
Pancreastatin inhibits glucose-stimulated insulin secretion from pancreatic beta cells, reduces insulin sensitivity in peripheral tissues, and modulates glucagon secretion.
Health Claims & Evidence
Modulates insulin secretion
Biomarker for metabolic syndrome
Modulates glucose metabolism
Short-Term Effects
Insulin secretion inhibition, glucose elevation.
Long-Term Effects
Research use primarily.
Side Effects
Glucose dysregulation.
Contraindications
Not for self-administration.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Pancreastatin and insulin secretion
Tatemoto et al. · Nature · 1986
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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