Selank
Selank (Tuftsin analogue)
A synthetic analogue of the immunomodulatory peptide tuftsin. Developed in Russia as an anxiolytic and nootropic with a favorable safety profile and no dependence potential.
Mechanism of Action
Selank modulates GABA-A receptor activity, producing anxiolytic effects without sedation. It increases BDNF expression, stabilizes enkephalins (endogenous opioids), and modulates IL-6 and other cytokines, providing both cognitive and immune benefits.
Health Claims & Evidence
Reduces anxiety without sedation or dependence
Improves memory and learning
Immunomodulatory effects
Improves mood and emotional resilience
Short-Term Effects
Rapid anxiety reduction, improved mood, enhanced focus and verbal fluency.
Long-Term Effects
Sustained mood stabilization and cognitive improvements with cycling. No tolerance or dependence reported.
Side Effects
Extremely well-tolerated. Mild sedation at very high doses. No withdrawal effects reported.
Contraindications
Limited data in pregnancy. Use with caution alongside other GABAergic substances.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Selank as an anxiolytic peptide
Semenova et al. · Bulletin of Experimental Biology and Medicine · 2010
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
Related Peptides
Explore the research further
Our AI Research Advisor can help you explore the evidence on Selank and related peptides, and prepare an educational research summary.
Explore Research