Dynorphin
Dynorphin A (Kappa-Opioid Peptide)
A kappa-opioid receptor agonist with complex effects on pain, stress, and mood. Unlike mu-opioid agonists, kappa activation produces dysphoria and stress-like states.
Mechanism of Action
Dynorphin binds to kappa-opioid receptors (KOR), producing analgesia but also dysphoria, sedation, and stress-like states. KOR antagonists are being developed as antidepressants.
Health Claims & Evidence
Kappa-opioid receptor-mediated analgesia
Modulates stress and mood
Regulates reward and addiction pathways
Short-Term Effects
Analgesia, dysphoria, sedation.
Long-Term Effects
Research use primarily.
Side Effects
Dysphoria, sedation, psychotomimetic effects.
Contraindications
Not for self-administration.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Dynorphin and kappa-opioid receptor pharmacology
Chavkin et al. · Science · 1982
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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