Relaxin-3
Relaxin-3 (INSL7)
The most ancient member of the relaxin/insulin superfamily. Acts as a neuropeptide modulating stress, appetite, and arousal.
Mechanism of Action
Relaxin-3 binds to RXFP3 and RXFP4 receptors in the brain, modulating stress responses, appetite, and arousal. It activates the nucleus incertus, a key stress-response center.
Health Claims & Evidence
Modulates stress and anxiety responses
Regulates appetite and food intake
Modulates arousal and cognition
Short-Term Effects
Stress modulation, appetite changes.
Long-Term Effects
Research use primarily.
Side Effects
Limited human data.
Contraindications
Research use only.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Relaxin-3 and stress responses
Ma et al. · Proceedings of the National Academy of Sciences · 2007
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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