LK8
Angiostatin Fragment LK8 (Kringle 8)
The eighth kringle domain of plasminogen, LK8 is a potent endogenous anti-angiogenic peptide that inhibits endothelial cell proliferation and migration, with potential applications in tumor suppression and pathological angiogenesis.
Mechanism of Action
LK8 binds to angiomotin and other endothelial surface receptors, inhibiting VEGF-driven endothelial proliferation and tube formation. It induces apoptosis in activated endothelial cells while sparing quiescent vasculature, making it a selective anti-angiogenic agent.
Health Claims & Evidence
Inhibits pathological angiogenesis
Suppresses tumor growth via vascular starvation
Potential in age-related macular degeneration
Short-Term Effects
Unknown in humans.
Long-Term Effects
Unknown in humans.
Side Effects
Unknown in humans. Well-tolerated in animal studies.
Contraindications
Insufficient human data. Not for clinical use.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Angiostatin kringle domains and anti-angiogenic activity
Cao et al. · Journal of Biological Chemistry · 1996
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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