Semax
Semax (ACTH 4-10 analogue)
A synthetic analogue of ACTH 4-10, developed in Russia for cognitive enhancement and neuroprotection. Widely used for stroke recovery, ADHD, and cognitive optimization.
Mechanism of Action
Semax increases BDNF (brain-derived neurotrophic factor) and NGF (nerve growth factor) expression, enhancing neuroplasticity and neuronal survival. It modulates dopaminergic and serotonergic systems, improving focus, memory, and mood while providing neuroprotective effects.
Health Claims & Evidence
Enhances focus, memory, and cognitive performance
Increases BDNF and supports neuroplasticity
Neuroprotective after stroke or brain injury
Reduces anxiety and improves mood
Short-Term Effects
Rapid improvement in focus and mental clarity within hours. Reduced brain fog and improved verbal fluency.
Long-Term Effects
Sustained neuroplasticity improvements, potential long-term neuroprotection with cycling.
Side Effects
Generally well-tolerated. Mild anxiety or overstimulation at high doses. Rare reports of irritability.
Contraindications
Use with caution in individuals with anxiety disorders or bipolar disorder. Avoid combining with stimulants without medical guidance.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Semax and BDNF expression in the rat brain
Dolotov et al. · Journal of Neurochemistry · 2006
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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