Palmitoyl Tripeptide-1
Palmitoyl-Gly-His-Lys (Pal-GHK)
A palmitoylated derivative of the GHK tripeptide that penetrates the lipid barrier of skin to stimulate collagen and elastin synthesis, reducing the appearance of fine lines and wrinkles.
Mechanism of Action
Palmitoyl Tripeptide-1 binds to TGF-β receptors on fibroblasts, upregulating collagen I, III, and VI synthesis. The palmitoyl chain enhances skin penetration through the stratum corneum, delivering the active GHK signal to dermal fibroblasts.
Health Claims & Evidence
Stimulates collagen I, III, and VI synthesis
Reduces depth and appearance of wrinkles
Improves skin firmness and elasticity
Short-Term Effects
Improved skin hydration and texture within 2–4 weeks of consistent use.
Long-Term Effects
Progressive reduction in fine lines and wrinkles with continued use over 3+ months.
Side Effects
Excellent tolerability profile. Rare cases of mild contact sensitivity.
Contraindications
No known contraindications at standard cosmetic concentrations.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Palmitoyl tripeptide-1 and skin aging
Lintner et al. · International Journal of Cosmetic Science · 2002
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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