Tuftsin
Tuftsin (Thr-Lys-Pro-Arg)
A tetrapeptide derived from IgG that stimulates phagocytosis, NK cell activity, and macrophage function. The parent peptide of Selank.
Mechanism of Action
Tuftsin binds to tuftsin receptors on macrophages, neutrophils, and NK cells, stimulating phagocytosis, cytokine production, and anti-tumor activity.
Health Claims & Evidence
Stimulates phagocytosis and innate immunity
Enhances NK cell activity
Anti-tumor and anti-infection effects
Short-Term Effects
Enhanced phagocytosis, improved immune response.
Long-Term Effects
Potential for sustained immune optimization.
Side Effects
Generally well-tolerated.
Contraindications
Use with caution in autoimmune conditions.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Tuftsin and macrophage activation
Najjar et al. · Journal of Biological Chemistry · 1970
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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