Somatostatin
Somatostatin (Growth Hormone-Inhibiting Hormone)
A hypothalamic hormone that inhibits GH, insulin, glucagon, and GI hormone secretion. Octreotide (synthetic analogue) is FDA-approved for acromegaly and carcinoid tumors.
Mechanism of Action
Somatostatin binds to SSTR1-5 receptors, inhibiting adenylyl cyclase and reducing cAMP. This suppresses GH, insulin, glucagon, TSH, and multiple GI hormones.
Health Claims & Evidence
Inhibits GH secretion in acromegaly
Reduces GI hormone secretion
Anti-tumor effects in neuroendocrine tumors
Short-Term Effects
Rapid GH and GI hormone suppression.
Long-Term Effects
Sustained GH control in acromegaly with long-acting analogues.
Side Effects
GI symptoms, gallstones, glucose dysregulation.
Contraindications
Use with caution in diabetes.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Somatostatin and GH regulation
Brazeau et al. · Science · 1973
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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