α-MSH
Alpha-Melanocyte Stimulating Hormone (α-MSH)
A naturally occurring melanocortin peptide that stimulates melanin production and has potent anti-inflammatory and neuroprotective properties.
Mechanism of Action
α-MSH binds to MC1R (stimulating melanin), MC3R and MC4R (reducing inflammation and appetite), and MC5R (regulating exocrine glands). It activates cAMP pathways in melanocytes and anti-inflammatory pathways in immune cells.
Health Claims & Evidence
Stimulates melanin production and skin tanning
Potent anti-inflammatory effects
Neuroprotective effects
Short-Term Effects
Skin tanning, anti-inflammatory effects, mild appetite suppression.
Long-Term Effects
Sustained tan with maintenance dosing.
Side Effects
Nausea, flushing, potential mole darkening.
Contraindications
Avoid with melanoma history. Monitor skin changes.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Alpha-MSH and melanocortin receptor pharmacology
Cone et al. · Nature Reviews Neuroscience · 2005
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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