Secretin
Secretin
A GI hormone that stimulates pancreatic bicarbonate secretion and has been studied for autism spectrum disorder. FDA-approved for diagnostic use.
Mechanism of Action
Secretin binds to secretin receptors on pancreatic ductal cells, stimulating bicarbonate and water secretion. It also modulates gastric acid secretion and has CNS effects via secretin receptors in the brain.
Health Claims & Evidence
Stimulates pancreatic bicarbonate secretion
Diagnostic tool for pancreatic function
Potential benefit in autism spectrum disorder
Short-Term Effects
Pancreatic bicarbonate secretion, gastric acid reduction.
Long-Term Effects
Diagnostic use only.
Side Effects
Flushing, nausea, abdominal cramping.
Contraindications
Avoid with acute pancreatitis.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Secretin and pancreatic function
Bayliss et al. · Journal of Physiology · 1902
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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