Angiotensin 1-7
Angiotensin-(1-7)
A heptapeptide of the renin-angiotensin system that counteracts the effects of Angiotensin II. Has cardioprotective, anti-fibrotic, and anti-inflammatory properties.
Mechanism of Action
Angiotensin 1-7 binds to Mas receptors, activating NO and bradykinin pathways. It counteracts Angiotensin II by promoting vasodilation, reducing fibrosis, and having anti-inflammatory effects. It is produced by ACE2 cleavage of Angiotensin II.
Health Claims & Evidence
Cardioprotective and anti-fibrotic effects
Reduces blood pressure
Anti-inflammatory effects
Short-Term Effects
Potential blood pressure reduction, anti-inflammatory effects.
Long-Term Effects
Theoretical cardioprotective and anti-fibrotic benefits.
Side Effects
Limited human data. Potential hypotension.
Contraindications
Use with caution in hypotension.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Angiotensin-(1-7) and cardiovascular protection
Santos et al. · Regulatory Peptides · 2003
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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