PNP Peptide
Pro-Asn-Pro (PNP)
A short tripeptide fragment derived from the C-terminus of neuropeptide Y with demonstrated neuroprotective and memory-enhancing properties in preclinical models.
Mechanism of Action
PNP modulates GABA-A receptor activity and interacts with neuropeptide Y receptor subtypes, producing anxiolytic and nootropic effects. It enhances long-term potentiation in hippocampal circuits and protects neurons from excitotoxic damage.
Health Claims & Evidence
Enhances memory consolidation and recall
Neuroprotective against excitotoxicity
Anxiolytic effects without sedation
Short-Term Effects
Possible acute anxiolytic and focus-enhancing effects based on animal data.
Long-Term Effects
Unknown in humans. Animal data suggests neuroprotective potential.
Side Effects
Unknown in humans. No significant adverse effects in animal studies.
Contraindications
Insufficient human data. Not for clinical use.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Neuropeptide Y fragments and cognition
Redrobe et al. · Neuropharmacology · 1999
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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