Oxytocin
Oxytocin (OT)
The 'bonding hormone' — a neuropeptide involved in social bonding, trust, anxiety reduction, and childbirth. Intranasal oxytocin is used in research for autism and social anxiety.
Mechanism of Action
Oxytocin binds to oxytocin receptors in the brain and periphery. Central effects include increased trust, reduced social anxiety, and enhanced social bonding. Peripheral effects include uterine contraction and milk ejection.
Health Claims & Evidence
Reduces social anxiety and improves social function
Enhances trust and social bonding
Potential benefit in autism spectrum disorder
Short-Term Effects
Reduced social anxiety, increased trust and prosocial behavior within 30–60 minutes.
Long-Term Effects
Potential for sustained social function improvements with regular use.
Side Effects
Generally well-tolerated intranasally. Rare: increased anxiety in some individuals, potential for dependency.
Contraindications
Use with caution in individuals with anxiety disorders — effects can be paradoxical.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Intranasal oxytocin and social cognition in autism
Guastella et al. · Biological Psychiatry · 2010
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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