Ac-SDKP
N-Acetyl-Seryl-Aspartyl-Lysyl-Proline (Ac-SDKP)
A naturally occurring tetrapeptide that inhibits hematopoietic stem cell proliferation and has potent anti-fibrotic properties in heart and kidney.
Mechanism of Action
Ac-SDKP inhibits hematopoietic stem cell entry into S-phase, protecting them from cytotoxic agents. It also inhibits TGF-beta-mediated fibrosis in cardiac and renal tissue.
Health Claims & Evidence
Potent anti-fibrotic effects in heart and kidney
Protects hematopoietic stem cells
Potential treatment for cardiac and renal fibrosis
Short-Term Effects
Anti-fibrotic effects, stem cell protection.
Long-Term Effects
Potential for sustained anti-fibrotic benefits.
Side Effects
Limited human data.
Contraindications
Limited human safety data.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Ac-SDKP and cardiac fibrosis
Peng et al. · Hypertension · 2001
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
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