Palmitoyl Tetrapeptide-7
Palmitoyl-Gly-Gln-Pro-Arg
A palmitoylated tetrapeptide that suppresses excess interleukin-6 (IL-6) production in the skin, reducing chronic low-grade inflammation that accelerates skin aging.
Mechanism of Action
Palmitoyl Tetrapeptide-7 downregulates IL-6 and other pro-inflammatory cytokines in keratinocytes and fibroblasts. By reducing inflammaging, it preserves the extracellular matrix and supports collagen integrity. Often paired with Palmitoyl Tripeptide-1 as Matrixyl 3000.
Health Claims & Evidence
Reduces IL-6-mediated skin inflammation
Reduces wrinkle volume and depth
Supports skin barrier integrity
Short-Term Effects
Reduced skin redness and irritation; improved texture within 4 weeks.
Long-Term Effects
Significant wrinkle reduction and improved skin density with 3+ months of use.
Side Effects
Excellent safety profile. No significant adverse effects reported at cosmetic concentrations.
Contraindications
No known contraindications.
This profile is provided for educational research only. It is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Verify primary sources and consult a qualified healthcare professional for medical decisions.
Research Papers
Matrixyl 3000 clinical efficacy
Sederma Research · Cosmetics & Toiletries · 2005
Educational research only. This profile is not a treatment recommendation or dosing guide. Human evidence, safety information and regulatory status vary by substance. Consult a qualified healthcare professional for medical decisions.
Related Peptides
Explore the research further
Our AI Research Advisor can help you explore the evidence on Palmitoyl Tetrapeptide-7 and related peptides, and prepare an educational research summary.
Explore Research