Peptide Bioregulators Thymalin and Epithalamin Increase the Lifespan of Old Mice
Anisimov VN, Khavinson VKh, Provinciali M, Alemi M, Franceschi C
Bulletin of Experimental Biology and Medicine · Vol. 142(2) · pp. 202–205 · 2006
Controlled animal study demonstrating that combined treatment with Thymalin and Epithalon significantly extends lifespan in aged mice. Provides the strongest animal evidence for the longevity effects of peptide bioregulators and establishes the rationale for combination longevity protocols.
Citation
Key Findings
Combined Thymalin + Epithalon treatment extended mean lifespan by 25–30% in aged mice
Reduced incidence of spontaneous tumors in treated animals
Improved immune function (T-cell activity, NK cell cytotoxicity) in aged animals
Normalized hormonal parameters including melatonin and cortisol
Synergistic effects of combination greater than either peptide alone
Methodology
Longitudinal survival study in aged C3H/He mice. Kaplan-Meier survival analysis, tumor incidence monitoring, immune function assays, and hormonal profiling.
Limitations
Mouse lifespan data; translation to human longevity requires clinical validation. Optimal dosing and timing for humans not established.
Protocols Using This Research
Tags
Educational use only. Research summaries are provided for informational purposes. Always consult the original publication and a qualified healthcare provider before making clinical decisions.
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