Angiotensin-(1-7) Is an Endogenous Ligand for the G Protein-Coupled Receptor Mas
Santos RA, Simoes e Silva AC, Maric C, Silva DM, Machado RP, de Buhr I, Heringer-Walther S, Pinheiro SV, Lopes MT, Bader M, Mendes EP, Lemos VS, Campagnole-Santos MJ, Schultheiss HP, Speth R, Walther T
Proceedings of the National Academy of Sciences · Vol. 100(14) · pp. 8258–8263 · 2003
Landmark paper identifying the Mas receptor as the functional receptor for Angiotensin-(1-7), establishing the ACE2/Ang-(1-7)/Mas axis as a counter-regulatory arm of the renin-angiotensin system with cardioprotective, vasodilatory, and anti-fibrotic effects.
Citation
Key Findings
Angiotensin-(1-7) is the endogenous ligand for the Mas G protein-coupled receptor
Mas receptor activation produces vasodilation, anti-proliferative, and anti-fibrotic effects
ACE2/Ang-(1-7)/Mas axis opposes the vasoconstrictive ACE/Ang-II/AT1 axis
Mas knockout mice show impaired cardiac function and increased fibrosis
Establishes therapeutic rationale for Ang-(1-7) in hypertension and heart failure
Methodology
Receptor binding studies, Mas knockout mouse cardiovascular phenotyping, vascular reactivity assays, and cardiac fibrosis quantification.
Limitations
Foundational mechanistic study; clinical translation of Ang-(1-7) therapy still in development. Delivery challenges due to short half-life.
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Educational use only. Research summaries are provided for informational purposes. Always consult the original publication and a qualified healthcare provider before making clinical decisions.
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